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Polymeric antigens with a repeating structure in contrast are able to activate B cells probably because they can cross-link and cluster Ig molecules on the B cell surface. In the absence of co-stimulators monomeric antigens are unable to activate B cells.
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Within the CD4 population we analyzed markers commonly related to T cell activation HLA-DR and CD38 senescence and exhaustion CD57 and PD1 differentiation CD45RA CCR7 CD28 and CD27.
. T cell independent B cell activation occurs without the assistance of T cell co-stimulatory proteins.
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